The Lemoore train depot opened in 1912 and played a crucial role in the growth of Lemoore, California, into the early 20th century. The Southern Pacific Railroad reached Lemoore in 1877, and the depot became a vital hub for shipping agricultural products like wheat, wool, and fruit. This infrastructure also redirected the town's business growth towards the railroad station, establishing E (Front) and D Streets as the main business avenues.

Later when the building was in disrepair, it was torn down in the 1960's. However, the City of Lemoore purchased and moved the Strathmore train depot to Lemoore and commissioned repairs to make a 'look-a-like' to the original depot in 2003.

Valley Pure currently resides in the Lemoore Train Depot building.